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Curcumin Clinical Studies
The following documents are available in Adobe PDF format, click here to download the FREE Reader if needed. Chemoprevention of GI Cancers with Dietary Agents: Are We There Yet?AGA Perspectives—February 17, 2008 Back to basics: how natural products can provide the basis for new therapeuticsInforma Healthcare—2007 Targeting Cell Signaling Pathways for Drug Discovery: An Old Lock Needs a New KeyJournal of Cellular Biochemistry—2007 From Ancient Medicine to Modern Medicine: Ayurvedic
Concepts of Health and Their Role in Inflammation and CancerJournal of the Society for Integrative Oncology—December 21, 2006 Pretherapy nuclear factor-KB status, chemoradiation resistance, and metastatic progression in esophageal carcinomaAmerican Association for Cancer Research—November 2006 Nuclear Factor-kB (NF-kB) Is Frequently Expressed in Lung Cancer and Preneoplastic LesionsAmerican Cancer Society—October 31, 2006 Molecular targets of dietary agents for prevention and therapy of cancerElsevier Ireland Ltd—June 21, 2006 Association of Activated Transcription Factor Nuclear
Factor kB With Chemoradiation Resistance and Poor Outcome in Esophageal CarcinomaJournal of Clinical Oncology—February 10, 2006 Oncologic, Endocrine & MetabolicFrom traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer Ashley Publications—2006 Nuclear Factor-kB: A Holy Grail in Cancer Prevention and TherapyBentham Science Publishers Ltd—2006 All pathways to cancer apoptosis meeting in
Thiruvananthapuram (India)International Symposium on Translational Research: Apoptosis & Cancer—Trivandrum (India)—December 18-21, 2005 Preventive and Therapeutic Effects of Plant Polyphenols through Suppression of Nuclear Factor-Kappa BNavindra P. Seeram-UCLA, Los Angeles; Haruyo Ichikawa, Shishir Shishodia, and Bharat B. Aggarwal - University of Texas, Houston—July 27, 2005 Chemosensitization and Radiosensitization
of Tumors by Plant PolyphenolsAntioxidants & Redox Signaling—June 27, 2005 Nuclear Factor-kB As Target for ChemopreventionCytokine Research Section, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, U.S.A.—December 6, 2004
Redox Regulation of Apoptosis by Members of the TNF SuperfamilyAntioxidants & Redox Signaling—October 17, 2004. Pro-apototic and Anti-apoptoitic Effects of Tumor Necrosis Factor in Tumor CellsRole of Nuclear Transcription Factor NF-kB Bharat B. Aggarwal and Yasunari Takada—Cytokine Research Section, Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, Houston, TX Role of chemopreventive agents in cancer therapy
Thambi Doraiaa and Bharat B. Aggarwalb—July 7, 2004 aComprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY 10466, USA
bCytokine Research Section, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA |
Additional Resources:
Cancer Letters Volume 277, Issue 1, Pages 1-120—May 8, 2009 Volume 215, Issue 2, Pages 129-256—November 25, 2004 Elsevier Ireland Ltd. Benefits of JIVA™ Curcumin and Fermented Soy Suggested Dosage for Serious Conditions Curcumin In The News Dosage Studies:
Cell cycle control as a basis for cancer chemoprevention through dietary agents.
Meeran SM, Katiyar SK. Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL35294, USA The development of cancer is associated with disorders in the regulation of the cell cycle. The purpose of this review is to briefly summarize the known sequence of events that regulate cell cycle progression with an emphasis on the checkpoints and the mechanisms cell employ to insure DNA stability in the face of genotoxic stress. Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinases (CDK) molecules. The cyclins are CDK binding partners which are required for kinase activity and their protein levels are intimately linked to the cell cycle stage. CDK activity can be regulated by other mechanisms, such as phosphorylation events, that may contribute to deregulation of cell cycle and the development of cancer. While fruits and vegetables are recommended for prevention of cancer, their active ingredients and mechanisms of action are less well understood. Here, we briefly present evidence that dietary agents identified from fruits and vegetables can act to modulate the effects of deregulated cell cycle checkpoints, and that this may contribute to the prevention of cancer. The agents include apigenin (celery, parsley), curcumin (turmeric), (-)-epigallocatechin-3-gallate (green tea), resveratrol (red grape, peanuts and berries), genistein (soybean), and silymarin (milk thistle). The teachings of Hippocrates are still true "let food be thy medicine and medicine be thy food". |
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